Human CD74 is expressed intracellularly and on the cell surface of MHC Class II positive cells such as B cells, monocytes, macrophages, Langerhans cells and dendritic cells. CD74 has several important functions relating to antigen presentation by MHC Class II molecules (2).
Isotype: Murine IgG2a
Immunogen: RPMI 1788 cell line
Specificity: Antibody M-B741 recognizes the CD74 molecule of about 33 kd (1).
1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 568-574.
2. P. Romagnoli & R.N. Germain, (1995) J Exp Med 182: 2027-2036.