Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the tumor necrosis factor gene family (3).
Isotype: Murine IgG1
Immunogen: Human WM-1 (Waldenström’s macroglobulinemia) cell line
Specificity: Antibody BU69 recognizes the CD70 molecule of approximately 30 kd (3).
Functional Application: Antibody BU69 blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells(5).
1. R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773.
2. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.
4. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.