anti-CD70 R-PE Conjugate

Human CD70 is not present on resting lymphocytes.  CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells.  CD70 is a ligand for CD27 and it is also a member of the tumor necrosis factor gene family (3). 

Isotype:  Murine IgG1

Immunogen: Human WM-1 (Waldenström’s macroglobulinemia) cell line

Specificity: Antibody BU69 recognizes the CD70 molecule of approximately 30 kd (3).

Functional Application: Antibody BU69 blocks the interaction between CD27 and CD70, and has been shown to  inhibit T cell proliferation induced by dendritic cells(5).

References:

1.  R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773.

2.  M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.

4. K. Agematsu, et al, (1995) J Immunol  154: 3627-3635.

5. S Iwamoto, A Miyazaki, et al, (2005) J Leuk Biol 78: 383-392.

6. Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7. P.J. Adams, A.L. Harris, et al.(2006) British J Cancer 95:298-306.

8. C Muller, R Kuppers, et al.(2010) Intl Immunol 22(4):289-298.

9.  H Yokoi, H Yoshikawa, et al (2003) Lymphology 36: 3674-83. PMID: 12926832

USD $275.00
In cart: 0
= $275.00
Catalog #:
222-050
Form:
R-PE
Size:
120 tests
Alternate Name:
Ki-24
Clone:
BU69
Applications:
EIA, FC(9), ICC(7), IHC(8)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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