anti-CD54 (D1) Purified (with Antibiotics)

Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1).  CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

Antibodies 15.2 and 8.4A6 (cat #206-020) each bind to a distinct epitope of CD54 and are suitable as a matched pair for EIA using 15.2 as capture and Biotinylated 8.4A6(cat# 206-030) as detector.

Isotype: Murine IgG1 kappa

Immunogen: Human monocytes

Specificity: Antibody 15.2 recognizes the D1 domain of the CD54 molecule of 90 kd (1, 2).  It has been reported to be cross reactive with porcine CD54.

Functional Application: Antibody 15.2 inhibits CD54 binding to LFA-1.


1.  A.R. Berendt, et al, (1992) Cell  68: 71-81.

2.  I. Dransfield, et al, (1992) J Cell Biol  116: 1527-1535.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1548-1550.

4.  P.L. Reilly, et al, (1995) J Immunol  155: 529-532.

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100 µg