anti-CD50 Purified (with Antibiotics)

Human CD50 (ICAM-3) is an adhesion molecule that interacts with LFA-1 (CD18/CD11a) and provides a costimulatory signal for T cells (1, 2, 3) which is thought to be essential for initiation of immune responses.

Isotype: Murine IgG2b

Immunogen: Stimulated human leukocytes

Specificity: Antibody 186-2G9 recognizes the D1 domain of the ICAM-3 molecule of 130 kd (4).

Functional Applications: Antibody 186-2G9 blocks binding of CD11a (LFA-1) to CD50 (ICAM-3)

References:

1.  Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford  (1995) p. 1546-1547, 1578-1579.

2.   C.L. Holness, et al, (1995) J Biol Chem  270: 877-884.

3.  Y. van Kooyk, et al, (1996) J Exp Med 183: 1247-1252.

4.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 403-409.

USD $175.00
In cart: 0
= $175.00
Catalog #:
201-020
Form:
Pur/WA
Size:
100 µg
Alternate Name:
ICAM-3
Clone:
186-2G9
Applications:
FC, PS

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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