anti-CD47 R-PE Conjugate

Human CD47 (IAP, Integrin Associated Protein) is a broadly expressed  Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular c-terminal domain.  It interacts with it ligand SIRP alpha (CD172a, Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis.  The CD47-SIRPa axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC(2), Glioma(3) and Breast Cancer(4)

Isotype:  Mouse IgG1k

Immunogen:  Recombinant human CD47 (extracellular Ig domain)

Specificity: Clone ANC2F6 binds to an epitope within the extracellular Ig-like domain of human CD47.

References:

1) Xiaojuan Liu, Yang-xin Fu, et al. (2017) J Hematol Oncol 10:12. doi:10.1186/s13045-016-0381-z PMID: 28077173.  

2) Wu L, Sun ZJ, et al. (2018) Oncoimmunology 7(4): e1397248. Doi: 10.1080/2162402X.2017.1397248.

3) Lif F, Jiang X, et al. (2017) Oncoimmunology 7(2): e1391973. doi: 10.1080/2162402X.2017.1391973.

4) Norman MZ, Janji B, et al. (2018) Oncoimmunology. 7(4):e1345415. doi: 10.1080/2162402X.2017.1345415.

USD $350.00
In cart: 0
= $350.00
Catalog #:
198-050
Form:
R-PE
Size:
120 tests
Alternate Name:
IAP, Integrin Associated Protein
Clone:
ANC2F6
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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