anti-CD45 Allophycocyanin

Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes.  CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments.  CD45 plays an essential role in lymphocyte activation (2).

Isotype: Murine IgG2a kappa

Immunogen: Peripheral blood mononuclear cells

Specificity: Antibody C11 recognizes all isoforms of CD45.

References:

1.  U. Dianzani, et al, (1992) Eur J Immunol  22: 365-371.

2.  I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol  12: 85-116.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 386-399.

4.  D. Leitenberg, et al, (1996) J Exp Med  183: 249-259.

5.  M Vigano,  de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.