Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. CD45 plays an essential role in lymphocyte activation (2).
Isotype: Murine IgM
Immunogen: Peripheral blood mononuclear cells
Specificity: Antibody 351C5 recognizes the CD45R isoforms of about 200-220 kd (1).
1. L.J. Murray, et al, (1985) Clin Exp Immunol 59: 315-326.
2. I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol 12: 85-116.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 394-397.
4. D. Leitenberg, et al, (1996) J Exp Med 183: 249-259