anti-CD45R FITC Conjugate

Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes.  CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments.  CD45 plays an essential role in lymphocyte activation (2).

Isotype: Murine IgM

Immunogen: Peripheral blood mononuclear cells

Specificity: Antibody 351C5 recognizes the CD45R  isoforms of about 200-220 kd (1).

References:

1.  L.J. Murray, et al, (1985) Clin Exp Immunol  59: 315-326.

2.  I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol  12: 85-116.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 394-397.

4.  D. Leitenberg, et al, (1996) J Exp Med  183: 249-259