anti-CD40 Purified (Preservative-free)

Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells.  CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells.  CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (3).

Isotype: Murine IgG1

Immunogen: Murine L cells transfectants expressing human CD40

Specificity: Antibody BE-1 recognizes the CD40 molecule of about 44 kd (1, 2).

Functional Application: Binding of cross linked BE-1 will partially activate B cells.

References:

1.  C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4: 732-738.

2.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 90-91.

3.  T.A. Foy, et al, (1996) Annu Rev Immunol  14:591-617.

4.  M.R. Kuhné , et al, (1997) J Exp Med  186:337-342.

USD $175.00
In cart: 0
= $175.00
Catalog #:
189-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
TNFRSF5
Clone:
BE-1
Applications:
EIA, FC, IP(4)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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