anti-CD40 Purified (Preservative-free)

Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells.  CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells.  CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (3).

Isotype: Murine IgG1

Immunogen: Murine L cells transfectants expressing human CD40

Specificity: Antibody BE-1 recognizes the CD40 molecule of about 44 kd (1, 2).

Functional Application: Binding of cross linked BE-1 will partially activate B cells.

References:

1.  C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4: 732-738.

2.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 90-91.

3.  T.A. Foy, et al, (1996) Annu Rev Immunol  14:591-617.

4.  M.R. Kuhné , et al, (1997) J Exp Med  186:337-342.