anti-CD17 Purified (Preservative-free)

Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets, and basophils (1).  CD17 expression is downmodulated on activated granulocytes. CD17 is an important componant in CD11b/CD18 mediated phagocytosis of microbes (2).

Isotype: Murine IgM

Immunogen: Human beta-2 microglobulin associated proteins from a detergent lysate of PBL

Specificity: Antibody Huly-m13 binds to CD17 on human myeloid cells. It does not recognize mouse LacCer (6).

References:

1.  Leukocyte Typing IV (W Knapp, et al, eds.)  Oxford University Press, Oxford  (1989) p. 877-879.

2.  Nakayama H, K Iwabuchi, et al. (2008) J Leukocyte Biol 83:728-741.

3. Rusciani A, Duca L, Sartelet H, Chatron-Colliet A, Bobichon H, et al. (2010)   PLoS ONE 5(11): e14010.

4.  Chatterjee S, Alsaeedi N, Hou J, Bandaru VVR, Wu L, et al. (2013)  PLoS ONE 8(5): e63726.

5.  Hulkova H, M Elleder, et al. (2005) Virchows Archiv 447(1): 31-44.

6.  K Iwabuchi, K Takamori, et al. (2015) Glycobiology 25(6): 655-68.  PMID: 25595946

7. H Nakamura, T Murayama, et al. (2017) J cell Biol 118(12): 4370-4382. PMID: 2844490DOI: 10.1002/jcb.26091

USD $175.00
In cart: 0
= $175.00
Catalog #:
166-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
Lactosylceramide, LacCer
Clone:
Huly-m13
Applications:
5)), FC, IHC(4)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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