anti-CD11b Allophycocyanin

Human CD11b (alpha M integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 3 (CR3) heterodimer which binds to ICAM-1, fibrinogen, C3b, and coagulation factor X.  CD11b expression is restricted to leukocytes, mainly to myeloid and NK cells.

Isotype: Murine IgG1

Immunogen: Human monocytes

Specificity: Antibody ICRF44  recognizes the human integrin alpha M subunit (CD11b) of about 165 kd (1, 3). It has been reported to be cross reactive with porcine CD11b as well as cynomolgus monkey CD11b (6).

Functional Application: Antibody ICRF44 blocks homotypic neutrophil and monocyte (FMLP induced) aggregation. ICRF44 blocks Trogocytic killing of Trichomonis vaginalis by human Neutrophil-like cells(7).

References:

1.  V. Mathotra, et al, (1986) Eur J Immunol  16: 1117-1123.

2.  B.L. Myones, et al, (1988) J Clin Invest  82: 640-651.

3.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 555-558, 560-562.

4.  H.R. Petty & R.F. Todd, (1993) J Leuk Biol  54: 492-494.

5.  Leukocyte Typig V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995)p. 1588-1590.

6. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

7. E N Trujillo, F Mercer et al. (Feb 2024) Parasite Immunology 46(2): e13025  https://doi.org/10.1111/pim.13025 PMID: 38372623

USD $300.00
In cart: 0
= $300.00
Catalog #:
159-060
Form:
APC
Size:
120 tests
Alternate Name:
CR3, Mac-1, integrinα M
Clone:
ICR44
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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