Human CD9 is strongly expressed on platelets, on early B cells and on activated T cells. CD9 is a member of the tetraspan family crossing the membrane four times (2). Both the N-terminal and C-terminal regions are on the cytoplasmic side of the plasma membrane. Recent studies indicate CD9 may be involved with calcium mobilization (3).
Isotype: Murine IgG1 kappa
Immunogen: Membrane antigen preparation of NALM-6 (human pre-B leukemia cell line)
Specificity: Antibody SN4 recognizes the Large Extracellular Domain (LED) (4) of human tetraspan CD9 molecule of about 24 kd (1).
1. Y. Luo, et al, (1989) Cancer Research 49: 706-710.
2. F. Lanza, et al, (1991) J Biol Chem 266: 10638-10645.
3. K. Kuroda, et al, (1995) J Immunol 155: 4427-4436.