The human CD1 genetic locus consists of five closely related genes (1). Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells (2). CD1 molecules have a specialized lipid antigen-presenting function (3).
Isotype: Murine IgG1 kappa
Immunogen: Membrane antigen preparation of human thymocytes
Specificity: Antibody SN13 is specific for the CD1b molecule of about 45 kd. Specificity was confirmed using CD1b transfectants.
1. Leukocyte Typing III (A.J. McMichael, et al, eds.) Oxford University Press, Oxford, (1987) p. 882.
2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 337-341.
3. E.M. Beckman, et al, (1994) Nature 372(6507): 691-694.
4. S M Hayes, K L Knight (2001) J Immunol 166(1): 403-410