anti-human Lambda R-PE Conjugate
Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex. There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains. L chains are divided into kappa or lambda classifications based on structural antigenic differences. All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.
Isotype: Murine IgG1
Immunogen: Human Ig
Specificity: Antibody ICO106 recognizes cell surface lambda chain on B cells
1. Basic and Clinical Immunology, Seventh edition (D. P. Sites & A. I. Terr, eds.) Appleton & Lange., Norwalk, CT (1991).