anti-MHC Class II Biotinylated

Human MHC Class II (HLA-DP, DQ & DR) molecules are expressed on dendritic cells, monocytes, macrophages, and myeloid beta cells.  MHC Class II molecules are heterodimers of polymorphic transmembrane a and b chains and generally bind exogenously derived peptides of about 10-17 amino acids.  MHC Class II molecules interact with the T cell receptor on CD4+ T cells.

Isotype: Murine IgG1

Immunogen: Purified (With Antibiotics) class II from JY cell line

Specificity: Antibody TDR31.1 recognizes a monomorphic class II beta chain epitope (1), and has been termed a “pan HLA II beta mAb” (8) since it cross reacts with other HLA haplotypes (7).

References:

1.  T.A. deKrester, et al, (1982) Eur J Immunol  12: 214-221.

2.  R. Busch & J.B. Rothbard, (1990) J Immunol Methods  134: 1-22.

3.  K.W. Wacherpfennig & J.L. Strominger, (1995) J Exp Med  181: 1597-1601.

4. Whitwell H L, A Ahmed, et al. (1984) Br J Cancer 49: 161-172.

5. Keller C W, J D Lunemann, et al. (2010) J Biol Chem 286(5): 3970-3980.

6. Yang J, T Mohanakumar, et al. (2004) Human Immunol 65: 692-699.

7.  D M Altmann, Trowsdale J, et al. (1990) Immunogenetics 32(1): 51-55. PMID: 1695613

8. Miyadera H,  K Tokunaga, et al. (2015) J Clin Invest 125(1): 275-91. PMID 25485681

USD $210.00
In cart: 0
= $210.00
Catalog #:
131-030
Form:
Biotin
Size:
100 µg
Alternate Name:
HLA-DP, HLA-DQ, HLA-DR, Major Histocompatability Complex
Clone:
TDR31.1
Applications:
5)), FC, IHC(Frozen Section (4), WB(6)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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