anti-TCR Cβ1 (APC)

Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4).

Isotype: Murine IgG2a

Immunogen: Human HA1.7 TCR beta chain expressed on transgenic mouse cells

Specificity: Antibody JOVI-1 recognizes human C beta 1 TCR gene product and reacts with 50-75% of T cells in normal human blood (1). JOVI-1 does not bind to TCR C beta 2 (5).

Functional Application: Antibody JOVI-1 is mitogenic for T cells expressing TCR C beta 1. Jovi-1 has been used to identify T-cell Leukemia(8), and other T cell malignancies(9).

References:

1. J.L. Viney, et al, (1992) Hybridoma 11: 701-713. PMID: 1284120

2. A. Weiss, (1993) Cell 73: 209-212.

3. M.M. Daris, (1995) Nature 375: 104.

4. S. Valitutti, et al, (1995) Nature 375: 148-151.

5. Paul M Maciocia, Martin A Pule, et al. (2017) Nature Medicine 23: 1416-1423. doi: 10.1038/nm.4444. Epub 2017 Nov 13. PMID: 29131157

6. M Shi, P Horn, et al. (April 11, 2019) Clinical Cytometry https://doi.org/10.1002.cyto.b.21782

7. H Berg, H Olteanu, et al. (April 2020) Clinical Cytometry https://doi.org/10.1002/cyto.b.21881

8. P. Horna, Min Shi, et al. (2021) Am J Clin Pathol 156(1): 139-148. doi: 10.1093/ajcp/aqaa214.doi: 10.1093/ajcp/aqaa214.

9. H Berg, H Olteanu, et al. (May 2021) Clinical Cytometry 100(3): 361-369. https://doi.org/10.1002/cyto.b.21881

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