anti-TCR Cβ1 Purified (Preservative-free)

Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains.  TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4).

Isotype:  Murine IgG2a

Immunogen: Human HA1.7 TCR beta chain  expressed on transgenic mouse cells

Specificity: Antibody JOVI-1 recognizes human C beta 1 TCR gene product and reacts with 50-75% of T cells in normal human blood (1).  JOVI-1 does not bind to TCR C beta 2 (5).

Functional Application: Antibody JOVI-1 is mitogenic for T cells expressing TCR C beta 1.  Jovi-1 has been used to ideintify T-cell Leukemia(8), and other T cell malignancies(9).

References:

1.  J.L. Viney, et al, (1992) Hybridoma 11: 701-713.  PMID: 1284120

2.  A. Weiss, (1993) Cell 73: 209-212.

3.  M.M. Daris, (1995) Nature 375: 104.

4.  S. Valitutti, et al, (1995) Nature 375: 148-151.

5.  Paul M Maciocia, Martin A Pule, et al. (2017) Nature Medicine 23: 1416-1423. doi: 10.1038/nm.4444. Epub 2017 Nov 13. PMID: 29131157

6. M Shi, P Horn, et al. (April 11, 2019) Clinical Cytometry https://doi.org/10.1002.cyto.b.21782

7.  H Berg, H Olteanu, et al. (April 2020) Clinical Cytometry https://doi.org/10.1002/cyto.b.21881

8. P. Horna, Min Shi, et al. (2021) Am J Clin Pathol 156(1): 139-148. doi: 10.1093/ajcp/aqaa214.doi: 10.1093/ajcp/aqaa214.

9. H Berg, H Olteanu, et al. (May 2021) Clinical Cytometry 100(3): 361-369. https://doi.org/10.1002/cyto.b.21881

USD $275.00
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= $275.00
Catalog #:
101-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
TCRCb1, TRBC1, TRBC-1
Clone:
Jovi-1
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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