Despite the pronounced proliferative effect of recombinant pentameric GITRL on T cells, MC38 adenocarcinoma tumor failed to regress due to suppressive effect of accumulating Treg  in tumor tissue and draining lymph node. “Authentic GITR Signaling Fails to Induce Tumor Regression unless Foxp3+ Regulatory T Ccells Are Depleted” Y.H. Kim, B.S. Kwon, et al. (2015) J […]

This Danish research group used a cocktail of Ancell Biotinylated anti tetraspan antibodies, anti-CD9, anti-CD63 and anti-CD81 to detect microvesicles captured on EV microarray.  The ability to characterize plasma derived exosomes in a high throughput manner may be very helpful in diagnosing cancer prognosis. “Potentials and capabilities of the Extracellular Vesicle (EV) Array” Malene Mǿller

Internalized ApoD is colocalized in intracellular vesicular compartments with CD147.  Downregulation of CD147 results in lower ApoD internalization.  Induction of CD147 overexpression resulted in increased ApoD internalization.  CD147 is a putative receptor for ApoD. “Apolipoprotein D Internalization Is a Basigin-dependent Mechanism” Ouafa Najyb, Louise Brissette, Eric Rassart (June 2015) J Biol Chem 290: 16077-16087. PMID:

This group demonstrated that physiologic levels of HDL act as an effective opsonin, facilitating uptake of M41-type Group A Streptococcus by human monocyte cell line U-937.  Pre incubation with anti-CD36 antibody (clone SM0) completely blocked this phagocytosis. “High-density lipoprotein acts as an opsonin to enhance phagocytosis of group A streptococcus by U937 cells.” Ling Liu,

“CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells”   J Leitner, P Steinberger, et al. (2015) J Immunol 195(2): 477-87. PMID: 26041540.   Related Ancell Research Products anti-CD2 mAb         (clone 1E7E8 UMCD2) anti-CD58(LFA-3)   (clone TS2/9)

“Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell–Mediated Suppression in the Context of Autoimmunity”  S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540.  PMID 26062995.   Ancell anti-Human CD161 antibody Products

Matched pair of anti-human CD155(PVR) mAbs for Flow Cytometry and EIA Clone ANC2B2    Purified                                 255-020 Biotinylated                        255-030   Clone ANC6A3  Purified                                 350-020 Biotinylated                        350-030   Recombinant Soluble Poliovirus Receptor CD155-muIg Binds to Ligand(s) Upregulated on Stimulated Human Peripheral Blood Lymphoid Cells Recombinant Human CD155(PVR)-muIg Purified CD155-muIg            555-020 Biotinylated

  “Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis” M Peled, A Mor, et al. Feb 10 2015 Inflammation PMID: 25663558     Related Ancell Research Products     Human CD279 (PD-1) Products (mAbs and Recombinant Proteins)   Superagonist anti-human CD28 mAb   anti-human CD3 mAb

  “Nitric Ooxide Donors Iincrease PVR/CD155 DNAM-1 Ligand Expression in Multiple Myeloma Cell: Role of DNA Damage Response Activation”  Cinzia Fionda, Marco Cippitelli, et al. (2015) BMC Cancer 15(1): 17 PMID: 25609078    Ancell human CD155 recombinant protein and monoclonal antibody products available soon!

“Semaforin Sema4D in the Immune System in Mulple Sclerosis.” E.M. Kulkina, I.V. Nekrasova, et al. (June 2014) Bull Exp Biol Med 157(2): 234-237. PMID 24952493 “Expression of Semaphorin CD100 on Peripheral Blood T-Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis”  T.N. Trushnikova, I.V. Nekrasova, et al. (Oct 2013) Multiple Sclerosis 113(10 pt 2): 47-51. PMID 24300815