Featured product: Ancell anti-CD105/FITC clone SN6 In these studies, Mesenchymal Stem/Progenitor cells show potential for repairing damaged joint tissue, and restoring liver function.  After enriched by sorting, and expansion in culture, the phenotype of resulting stem cell populations are:  CD105+, CD29+, CD166+, CD44+, CD45-, CD31-. 1) “Adipose tissue-derived mesenchymal stem cells as a source of […]

Featured product: Ancell Biotinylated mAb cocktail effective for Negative selection of Low Density Granulocyte(LDG) population from Systemic Lupus Erythematosis (SLE) patient blood. “A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs “ M.F. Denny, M.J. Kaplan, et al.  (2010) J Immunol  184(6): 3284-3297

Featured Products: F(ab’)2 Fragments of anti-CD64(FcgRI), anti-CD32(FcgRII), and anti-CD16(FcgRIII) for Human Fc Receptor and Immune Complex  Research Low Endotoxin and Essentially Free of Intact Antibody, these dimericantibody fragments block Immunoglobulin binding to their repective receptors anti-human CD64 (FcgRI)F(ab’)2 clone 10.1 anti-human CD32 (FcgRII) F(ab’)2 clone 7.3 anti-human CD16 (FcgRIII) F(ab’)2 clone 3G8 Literature Citations Inhibition

New human biologically active CD273 ( B7-DC, PD-L2) recombinant protein and other related products now available!

SW480 is a primary Colon Epithelial Adenocarcinoma tumor line and SW620 is a metastasized variant of this derived from lymph node.  Differential analysis of surface markers may give insight into tumor metastatic potential and/or mechanisms.   “Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell Lines”

New anti-CD269 (BCMA) antibody available!   Purified  (with antibiotic)      catalog # 269-020   Purified  (preservative-free)  catalog # 269-020

Ancell is proud to be a sponsor of the 2012 Autumn Immunology Conference in Chicago Nov 16th -Nov 19th. Visit us at booth #18!  

“Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients”   Kwek S S, L Fong, et al. (Oct 2012)  J Immunol 189(7): 3759-3766.  “…advanced prostate cancer patients who clinically respond to treatment also develop enhanced Ab responses to a higher number of Ags than nonresponders…” Relevant Ancell Products Anti-CD152(CTLA-4) blocking mAb

”CD49d provides access to “untouched” human Foxp3 Treg free of contaminating effector cells” Kleinewietfeld M, K Falk, et al. (2012) Blood 113(4): 827-836.   Magnetic depletion of PBMC using anti-CD127 (Clone hIL7R-M21) and anti-CD49d (Clone BU49) mAbs to yield a pure population of Foxp3 + Treg cells!   Relevant Ancell products:  anti-CD49d (clone BU49) anti-CD127

“B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression level on T Cell Subsets” M. Mkrtichyan,  S.N. Khleif, et al. (2012) J Immunol 189(5): 2338-2347.   Engagement of CD279(PD-1) by recombinant CD273 (B7-DC)-muIg enhances effect of anti-tumor vaccine in mice. Two proposed mechanisms by which this recombinant protein may augment anti tumor