New anti-CD269 (BCMA) antibody available!   Purified  (with antibiotic)      catalog # 269-020   Purified  (preservative-free)  catalog # 269-020

Ancell is proud to be a sponsor of the 2012 Autumn Immunology Conference in Chicago Nov 16th -Nov 19th. Visit us at booth #18!  

“Diversity of Antigen-Specific Responses Induced In Vivo with CTLA-4 Blockade in Prostate Cancer Patients”   Kwek S S, L Fong, et al. (Oct 2012)  J Immunol 189(7): 3759-3766.  “…advanced prostate cancer patients who clinically respond to treatment also develop enhanced Ab responses to a higher number of Ags than nonresponders…” Relevant Ancell Products Anti-CD152(CTLA-4) blocking mAb

”CD49d provides access to “untouched” human Foxp3 Treg free of contaminating effector cells” Kleinewietfeld M, K Falk, et al. (2012) Blood 113(4): 827-836.   Magnetic depletion of PBMC using anti-CD127 (Clone hIL7R-M21) and anti-CD49d (Clone BU49) mAbs to yield a pure population of Foxp3 + Treg cells!   Relevant Ancell products:  anti-CD49d (clone BU49) anti-CD127

“B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression level on T Cell Subsets” M. Mkrtichyan,  S.N. Khleif, et al. (2012) J Immunol 189(5): 2338-2347.   Engagement of CD279(PD-1) by recombinant CD273 (B7-DC)-muIg enhances effect of anti-tumor vaccine in mice. Two proposed mechanisms by which this recombinant protein may augment anti tumor

Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo. Zou T, Kambayashi T. et al. J Immunol. 2012 Jul 1;189(1):28-32. It has been thought that proliferation of T regulatory cells in vivo was dependent on signaling from T cell receptor –MHC Class II interaction.  Zou

“Human Th17 Cells Express High Levels of Enzymatically active Dipeptidylpeptidase IV (CD26)” Bengsch B, R Thimme, et al, (2012) J Immunol 188(11): 5438-5447. In transwell assays, CD26(bright) Th17 cells inhibited chemotaxis of CXCR4+ Th1 T cells towards CXCL12.   CD26 appears to be an interesting and useful marker for Th17 autoimmunity. Ancell anti-CD26 reagents (clone 202.36):

A link found between autoimmune antibody specificity to Citrullinated Protein and development of Rheumatoid Arthritis. “Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells”  Maria F. Bellatin, Peter Stastny, et al. (2012) J Immunol 188(7): 3542-3550 Ancell has a large selection of Biotinylated anti-human monoclonal antibodies which would be useful for sorting and/or identifying

Levels of the proinflammatory leptin correlated inversely with expansion of CD25+CD4+Foxp3+ T regulatory cells in a Systemic Lupus Erythematosus mouse model (NZB/W).  This could lead to a leptin-based immunotherapy.”Cutting Edge: Fasting Induced Hypoleptinemia Expands Functional Regulatory T cells in Systemic Lupus Erythematosus”Yaoyang Liu, Yiyun Yu, Antonio La Cava, (2012) J Immunol 188: 2070-2073.  Relevant Ancell

 Increased Expression of CD229(SLAMF3) and CD352(SLAMF6)  in SLE T Lymphocytes Promotes Th17 Differentiation Chatterjee M., G.C. Tsokos, et al. (2012) J Immunol 188: 1206-1212.