BTLA pathway possible mechanism of Lymphoma escape

The BTLA(CD272)-HVEM(CD270) pathway is an important regulatory mechanism for gamma/delta T cell proliferation. A subset of gamma/delta T cells can be induced to have potent anti-Lymphoma activity.  The amount of BTLA present on cell surface of these cells inversely correlates with their degree of differentiation. Blockade of this pathway can increases T cell signaling ability, […]

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Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients

Lower Frequencies of Down-regulatory Fc receptor CD32B on Memory B cells in Rheumatoid Arthritis patients “CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis”  Xiaoyu Zhang, Scott E. Strome, et al. (2013 June 15,) J Immunol 190(12): 6015-22.   In RA patient samples, CD154 T cell expression levels correlated with

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anti-CD105 fluorescent conjugates for phenotypic analysis of Mesenchymal Stem Cells

Featured product: Ancell anti-CD105/FITC clone SN6 In these studies, Mesenchymal Stem/Progenitor cells show potential for repairing damaged joint tissue, and restoring liver function.  After enriched by sorting, and expansion in culture, the phenotype of resulting stem cell populations are:  CD105+, CD29+, CD166+, CD44+, CD45-, CD31-. 1) “Adipose tissue-derived mesenchymal stem cells as a source of

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Biotinylated mAb cocktail effective for isolating Low Density Granulocytes from SLE patient blood

Featured product: Ancell Biotinylated mAb cocktail effective for Negative selection of Low Density Granulocyte(LDG) population from Systemic Lupus Erythematosis (SLE) patient blood. “A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs “ M.F. Denny, M.J. Kaplan, et al.  (2010) J Immunol  184(6): 3284-3297

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CD64 FcγRI, CD32FcγRII, CD16FcγRIII F(ab’)2

Featured Products: F(ab’)2 Fragments of anti-CD64(FcgRI), anti-CD32(FcgRII), and anti-CD16(FcgRIII) for Human Fc Receptor and Immune Complex  Research Low Endotoxin and Essentially Free of Intact Antibody, these dimericantibody fragments block Immunoglobulin binding to their repective receptors anti-human CD64 (FcgRI)F(ab’)2 clone 10.1 anti-human CD32 (FcgRII) F(ab’)2 clone 7.3 anti-human CD16 (FcgRIII) F(ab’)2 clone 3G8 Literature Citations Inhibition

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Cell Surface Metastatic Markers for Colon Cancer SW480/SW620 Model

SW480 is a primary Colon Epithelial Adenocarcinoma tumor line and SW620 is a metastasized variant of this derived from lymph node.  Differential analysis of surface markers may give insight into tumor metastatic potential and/or mechanisms.   “Multiplex Flow Cytometry Barcoding and Antibody Arrays Identify Surface Antigen Profiles of Primary and Metastatic Colon Cancer Cell Lines”

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