Treatments for IgA-nephropathy reviewed

IgA Nephropathy is one of the leading causes of kidney failure worldwide. It is caused by production of IgA1 antibodies lacking galactose in their o-Glycan regions, which cause them to be auto antigenic and can lead to protein aggregates. Traditional treatments have been limited to kidney care lifestyle modification and high-dose long term glucocordicosteroids. More

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Targeting CD19 expression can overcome relapses in autoimmune patients treated with CD20 targeted therapy

“Can autoimmune disease be cured by deep CD19+ cell depletion?” Dan Suan, John Moore, Christopher C Goodnow. J Immunol. 2025 Jun 1;214(6):1075-1092. doi: 10.1093/jimmun/vkaf008. PMID: 40116909 The Authors review encouraging data from B cell autoimmune patients in relapse after CD20 treatments who were given CD19 CAR T cell treatment, or blinumomab anti-CD19 bispecific T cell

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TRBC1 specific Immunotherapy showing promise for T cell Lymphoma treatment

Autolus Therapeutics tested the toxicity and efficacy of AUTO4, a TRBC1 specific CAR cell therapeutic on 10 relapsed/refractory T cell lymphoma patients. This treatment appears to be safe with only minimal toxicity. The CAR T cells were shown to be residing in the majority of patient lymph nodes.Ancell anti-TRBC1/Biotin (clone Jovi-1) was used to sort

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SARS COV2 mRNA extended dose interval yielded improved B cell response but no difference in T cell response

Recipients who received 2nd Covid booster with a longer than recommended interval from 1st immunization had improved specific antibody response, but asimilar T cell response. This differential effect was nullified by a 3rdbooster. “Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters” JI Ahmed, CM Card, et al.

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PD-1 interaction is necessary for proper B cell memory development

“Is one lymphocyte’s brake another lymphocyte’s gas?” Thomas T Xu, Shiv Pillai. (Feb 7, 2025) Sci Immunol 10(104): eadw3656 doi: 10.1126/sciimmunol.adw365 PMID: 39919195 PD-1 (CD279) binding to its ligand PD-L1 (CD274) is down regulatory for T cell immune response in the context of cancer. However, studies are showing that this interaction is required for development

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Cyclophilan A is a ligand for RAGE

Cyclophilin A is a ligand for RAGE in thrombo-inflammation Peter Seizer, David Heinzmann, et al. (March 2024) Cardiovascular Research 120(4): 385–402, https://doi.org/10.1093/cvr/cvad189 Ancell anti-human CD147 mAb was used for detection and to block activation of cells by Cyclophilan A Related Ancell Products anti-human CD147( EMMPRIN) mAb

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Non Classical Monocytes inhibit Cancer metastasis in mouse models

“Non Classical” (CCR2+ CD16++ CD14+ MHC Class II+ CD209+) subset of mouse monocytes were expanded using NOD2 small-molecule activators. CCR2 enabled these cells to infiltrate tumors and inhibit metastasis in mouse models of colon, lung, breast and melanoma through CCL6 recruitment of NK cells. The monocyte CCR2/CCL2 axis merits further investigation for cancer intervention! “Inducible

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LTbR emerging as an important TAM checkpoint

Levels of LTbR (Lymphotoxin beta Recpeptor) on TAM (Tumor Associated Macrophage) inversely correlate with anti-tumor response, indicating an immunosuppresive role. This Chinese research group demonstrate that disrupting this expression in mice by silencing or knockout causes tumor regression in a mouse lung carcinoma model. “LTBR acts as a novel immune checkpoint of tumor-associated macrophages for

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