Ancell CD40-muIg/PE used to characterize Hyper IgM Syndrome
Hyper IgM Syndrome is an immune disorder usuallycaused by an X-linked mutation in the CD40L(CD154) gene. In this study,the authors were able to discern an altered CD40L phenotypein a patient. While anti-CD40L mAbs still recognized the molecule in flow cytometry, a recombinant CD40 reagent failed to bind. Genetic analysis determined this to be caused by […]
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