CD63 upregulation useful to track the activation state of lung Mast cells

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Stem Cell Factor (SCF) can activate Lung Mast cells through CD117 (c-kit) to become more responsive to IgE challenge in vitro.  Up regulation of CD63 can be used to track this activation

“Heterogeneity in the responses of human lung mast cells to stem cell factor” A. Lewis, J. Wan, B. Baothman, P. N. Monk, S. K. Suvarna, P. T. Peachell (Jan 2013) Clin Exp Allergy 43(1): 50-59.

Relevant Ancell Products:

anti-CD63 (clone AHN16.1)

anti-CD117 c-kit (Clone 57A5)