CD28 signaling is required for Follicular Regulatory T cell development.

In CD28 knockout mice, T_FR cells have diminished suppressive ability, and B cells cause systemic inflammation.

“B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells”

Ruan Zhang, Laurence A. Turka, et al

J Immunol December 15, 2017, 199 (12) 3972-3980; DOI: https://doi.org/10.4049/jimmunol.1700409