TIGIT – CD155 pathway

The TIGIT – CD155 regulatory pathway is emerging as an important element of immune function.  Studies using knockout mice demonstrate that this pathway is important in optimal NK effector cell function (activation and/or tolerance) (1) There is significant potential for the development of immunological drugs that could blockade this pathway, restoring anti-cancer immune response (2).

1) “Contribution of inhibitory receptor TIGIT to NK cell education.”He Y, Tian Z, et al. (2017) J Autoimmun 81: 1-12.  PMID:28438433

2) “TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy.” Dougall WC,  Anderson AC, et al. (2017) Immunol Rev 276(1): 112-120. PMID:28258695

 

Relevant Ancell Products

anti-CD155 mAb

Recombinant CD155-muIg

Recombinant TIGIT-muIg   (Available Soon!)