TIGIT blockade restores T cell function in pancreatic cancer model

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Blockade of CD155/TIGIT signaling in conjunction with PD-1 blockade and CD40 agonism restores T cell function in mouse pancreatic cancer model

“The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer” Freed-Pastor WA, Tyler Jacks, et al. (July 2021) Cancer Cell S1535-6108(21)00384-6. doi: 10.1016/j.ccell.2021.07.007

Relevant Ancell Immunology tools

anti-human TIGIT mAb

Recombinant human TIGIT-muIg

anti-human CD155 mAb (clone ANC6A3)

anti-human CD155 mAb (clone ANC2B2)

Recombinant human CD155-muIg