SARS COV2 mRNA extended dose interval yielded improved B cell response but no difference in T cell response

Recipients who received 2^nd Covid booster with a longer than recommended interval from 1^st immunization had improved specific antibody response, but asimilar T cell response. This differential effect was nullified by a 3^rdbooster.

“Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters” JI Ahmed, CM Card, et al. Front. Immunol. (26 March 2025)16 – 2025 https://doi.org/10.3389/fimmu.2025.1529134