CD273 binds to a distinct site on RGMb (Repulsive Guidance Molecule Family member B) from Bone Morphogenic proteins (BMP).  In mice, blockade of this interaction impaired development of respiratory tolerance.

“RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance”  Y Xiao, G J Freeman, et al. (2014) JEM 211(5): 943-959.

 

Relevant Ancell Human Research Products

anti-CD273(PD-L2) mAb

anti-CD279(PD-1) mAb

Recombinant CD279(PD-1)

Recombinant CD273(PD-L2)