Antibody GK1.5 binds to an extracellular epitope of the 55kd CD4 molecule present on a murine T cell subset (1,2). CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T Cell Receptor signaling. This clone has proven effective as a T cell depletion reagent(3).
Isotype: Rat IgG2bk
Immunogen: Mouse CTL-V4 membrane prep
1) Wilde DB, Fitch FW, et al. (1983) J Immunol 131(5):2178-2183.
2) Dialynas DP, Fitch FW, et al. (1983) J Immunol 131(5):2445-2451.