anti-mouse CD3ε R-PE Conjugate
Antibody 145-2C11binds to an extracellular epitope of the 25 kd CD3e molecule present on murine T cells (1). CD3 molecules associate with T cell Receptors and provide intracellular signaling mechanism. Cross linking cell surface CD3 with soluble or immobilized 145-2C11 can activate this mechanism(2).
Isotype: Armenian Hamster IgG
Immunogen: Mouse BM10-37 T cell membrane prep
References:
1) O Leo, J A Bluestone, et al. (1987) PNAS USA 84(5): 1374-1378.
2) L E Samelson, J A Bluestone, et al. (1987) J Immunol 139(8): 2708-2714.