CD27-muIg Biotinylated

Molecular Structure: A soluble molecule consisting of  murine CD8 alpha signal peptide residual amino acids and linker: (1)kpqapelrgs(10)

A CD70-reactive n-terminal section of  the mature extracellular domain of human CD27:

(11)kscperhywaqgklccqmcepgtflvkdcdqhrkaaqcdpcipgvsfspdhhtrphcescrhcnsgllvrnctitanaecacrngwqcrdkectecdplpnps (113)

linker (114)gt(115)

murine IgG2a Fc + hinge regions: (116) eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgk (348)

The molecule is dimeric with a predicted monomeric non glycosylated molecular weight of 39.3 kd.

Transfectant Cell Line: CHO                            

Human CD27 is a lymphocyte specific member of the tumor necrosis factor receptor family (TNFRSF7) and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells.  The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily(TNFSF7).  The CD27-CD70 interaction plays an important role in T cell activation.

Specificity: Recombinant soluble CD27-muIg binds to cell surface CD70 on Raji cells in FACS, and is reactive with recombinant CD70-muCD8 (cat #537-020), and anti-CD27 mAb clone M-T271 (cat #176-020). 

USD $425.00
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= $425.00
Catalog #:
543-030
Form:
Biotin
Size:
25 µg
Alternate Name:
T14
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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