CD137(4-1BB)-huIg FITC Conjugate

Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3).  CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2).  CD137 appears to be important for T cell proliferation and survival (4) and induces monocyte activation (5).

Molecular Structure: A soluble 55 kd fusion protein consisting of the extracellular (186aa) domain of human CD137 fused to human IgG1 Fc (4), with a predicted monomeric molecular weight of 44.1 kd.

Transfectant Cell Line: CHO

Functional Application: CD137 Ig fusion protein blocks binding of anti-human CD137 to activated CEM human tumor cells and also binds to CD137 Ligand on Raji cells. 

References:

1.   M.R. Alderson, et al, (1994) Eur J Immunol  24: 2219-2227.

2.   H.J. Gruss, and S.K. Dower, (1995) Blood  85: 3378-3404.

3.   B.A. Garni-Wagner, et al, (1996) Cellular Immunol  169: 91-98.

4.   H. Schwarz, et al, (1996) Blood  87: 2839-2845.

5.   J. Langstein, et al, (1998) J Immunol  160: 2488-2494.

USD $425.00
In cart: 0
= $425.00
Catalog #:
502-040
Form:
FITC
Size:
50 tests
Alternate Name:
4-1BB
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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