anti-CD166 Biotinylated

Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6 (1,2).  Human CD166 may be important for activation of T cells.

Isotype:  Murine IgG1

Immunogen:  Human thymic epithelial cells

Specificity: Antibody 3A6 recognizes the CD166 molecule of 100 kd.  It is cross reactive with bovine CD166 (8).

Functional Application: Antibody 3A6 blocks binding of CD6 to CD166. Antibody 3A6 has been used to identify mesenchymal progenitor cells populations (5,6).

References:

1.  M.A. Bowen, et al, (1995) J Exp Med 181:  2213-2220.

2.  M.A. Bowen, et al, (1996) J Biol Chem 271:  17390-17396.

3.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York  (1997) p. 459-465.

4.   Spaggiari G.M.,  L. Moretta, et al.  (2006) Blood 107(4): 1484-1490.

5.  K Richardson, I.M. Khan, C.W. Archer (2006) Eur Cell & Materials 12 (suppl 1): 70.

6.  R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246  doi:10.1371.

7.  O Ozbey,  I Ustunel, et al. (2014) Acta Histochem 116(5): 763-70.

8.  A Konno, W C Davis, et al. (2001) J Leuk Biol 69: 944-950.

9.  P DeLuca, A Colombini, et al. (Mar 3, 2020) Eur Cell Mater 39: 156-170  doi: 10.22203/eCM.v039a10  PMID: 32125689

USD $210.00
In cart: 0
= $210.00
Catalog #:
393-030
Form:
Biotin
Size:
100 µg
Alternate Name:
ALCAM
Clone:
3A6
Applications:
FC(7), IHC(8)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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