anti-CD161(NKR-P1A) Biotinylated

Immunogen: Activated human NK cells

Isotype: Murine IgG2b

Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells.  CD161 has been implicated in the regulation of NK cell mediated cytotoxicity. CD161 positive TH17 cells are resistant to Treg mediated suppression.(5).

Antibody B199.2 recognizes the dimeric 160 kd CD161 molecule.

Functional Application:  In MLR, blockade with antibody B199.2 caused a slight but significant reduction in the percentage of IFN gamma-expressing NK cells challenged with M. tuberculosis (4).

References:

1)  I.M. Bennett, et al, (1996) J Exp Med 184: 1845-1856. 

2)   L. Azzoni, et al, (1998) J Immunol 161: 3493-3500.

3)  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 307-317.

4) Schierloh P, MC Sasiain, et al. (2007) Infection and Immunity 75(11): 5325-5337.

5)  S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540.  PMID 26062995.

USD $235.00
In cart: 0
= $235.00
Catalog #:
388-030
Form:
Biotin
Size:
100 µg
Alternate Name:
NKR-P1A
Clone:
B199.2
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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