Human CD133 is a 117kd pentaspan transmembrane glycoprotein expressed by a subset of hematopoetic and other types of stem cells found in blood and a variety of tissues. Increased expression of CD133 may be a predictor of decreased prognosis in patients with metastatic cancer(3).
Isotype: Mouse IgG1k
Immunogen: WERI-Rb-1 retinoblastoma
Specificity: Antibody ANC9C5 recognizes epitope 1 of human CD133(AC133) present on full length CD133 transfectants, Y-79 retinoblastoma, and other cell types.
Functional Application: Antibody ANC9C5 has been used to image cancer stem cells in a colon carcinoma xenograft (4).
1) Miraglia S, Buck DW, et al. (1997) Blood 90(12): 5013-5021.
2) Shmelkov SV, Rafii S, et al. (2005) Int J Biochem Cell Biol 37(4): 715-9.