Human CD49f molecules are integrin alpha 6 chains that are expressed as heterodimers with CD29 (beta 1 integrin) or CD104 (beta 4 integrin) and function as adhesion receptors. CD49f is expressed on platelets, monocytes, T lymphocytes and thymoctyes. The ligands for CD49f/CD29 include laminin and invasion. CD49f/CD29 has been shown to associate with CD63 (3).
Isotype: Murine IgG1
Immunogen: UM-UC-9, human bladder cancer cells
Specificity: Antibody BQ16 recognizes the CD49f molecule of about 150 kd (1, 2).
1. M. Liebert, et al, (1993) Hybridoma 12: 67-80.
2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1619-1620.
3. F. Berditchevski, et al, (1995) J Biol Chem 270: 17784-17790