anti-CD44 (Pur/PF)

Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis, and lymphocyte homing (1).

Isotype: Murine IgG2a

Immunogen: Human peripheral myeloma cells

Specificity: Antibody BU75 recognizes epitope 2 of the CD44 molecule which interacts with hyaluronate (HA)mediating binding of lymphocytes to high endothelial venules (2, 3). This epitope appears to be conformation dependant (4).

Functional Application: Antibody BU75 blocks binding of HA to CD44 (2,7, 9), Induces FasL expression in T cells (6), and inhibits DNA sythesis and IL2R expression in activated T cells (5).

References:

1. B.F. Hynes, et al, (1993) Adv Immunol 54: 271-335.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1713-1742.

3. H.X. Liao, et al, (1995) J Immunol 155: 3938-3945.

4. J. Bajorath, A. Aruffo, et al. (1998) J Biol Chem 273: 338-343.

5. Sugiyama K, M Sakurai, et al (1999) Immunol Invest 28(2,3): 185-200.

6. Nakano, K, Y Tanaka, et al (2007) Apoptosis 12(1): 45-54.

7. Y Fujii, Y Tanaka, et al. (2003) FEBS Letters 539 (1-3): 45-50. PMID: 12650924.

8. H Kawashima, M Miyasaka, et al (2000) J Biol Chem 275: 35448-56. PMID: 10950950

9. T Tamura, H Sato, et al. (2016) Arthrits Res Ther 18(1): 121. PMID: 27039182.

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