CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132(IL-2Rg) to form a high affinity IL-7 receptor (1). CD127 engagement is necessary for T cell development in humans (2).
Isotype: Murine IgG1 kappa
Immunogen: Recombinant human CD127
Specificity: Antibody ANC8F2 recognizes an extracellular epitope of human recombinant and native CD127 in FACS and Enzyme Immunoassay.
1) Noguchi, M. et al., 1993, Science 262:1877.
2) Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348.
3) Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990;60:941.