anti-CD117 Biotinylated

Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF).   CD117 is expressed on almost all hematopoietic progenitor cells and receptor /ligand interaction is crucial for development of hematopoietic stem cells (2, 3).

Isotype: Murine IgG1

Immunogen: Human MO7e tumor cells

Specificity: Antibody 57A5 recognizes extracellular epitope 2 of the human CD117 molecule of about 150 kd.

Functional Application: Antibody 57A5 does not block binding of SCF (4).

References:

1.  L.K. Ashman, et al, (1994) J Cellular Physiol 158: 545-554.

2.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1856, 1882-1888.

3.  J.R. Keller, et al, (1995) Blood  86: 1757-1764.

4.  Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 816-818.

USD $210.00
In cart: 0
= $210.00
Catalog #:
338-030
Form:
Biotin
Size:
100 µg
Alternate Name:
c-kit, SCF5
Clone:
57A5
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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