Human CD100 is a transmembrane glycoprotein that belongs to the semaphorin gene family and is found on most hematopoietic cells except RBC, platelets and immature bone marrow cells. CD100 plays a key role in lymphocyte activation (2, 3). Interaction of CD100 with its ligand CD72 has implications in the mechanism of NK cell killing (4).
Isotype: Murine IgM
Immunogen: PHA stimulated human PBL
Specificity: Antibody 133-1C6 recognizes an extracellular epitope of the human CD100 molecule of about 150 kd.
1.) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 534-539.
2.) K.T. Hall, et al, (1996) Proc Natl Acad Sci USA 93:11780-11785.
3.) A. Elhabazi, et al, (1997) J Biol Chem 272: 23515-23520.
4.) S. Mizrahi, O Mandelboim, et al.(2007) PLoS ONE 2(9):e818.