anti-CD40 (clone EA-5) Purified (with Antibiotics)

Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells.  CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells.  CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (5).

Isotype: Murine IgG1

Immunogen: Murine L cells transfectants expressing human CD40

Specificity: Antibody EA-5 recognizes the CD40 molecule of about 44 kd (1, 2, 3).

Functional Application: Binding of cross linked EA-5 will partially activate B cells.

References:

1.  C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia  4: 732-738.

2.  A.W. Larson & T.W. LeBien, (1994) J Immunol  153: 584-594.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 547-556.

4.  E. Lindout, et al, (1995) J Exp med  181:1985-1995.

5.  T.M. Foy, R.J Noelle et al, (1996) Annu Rev Immunol  14:591-617.