anti-CD274 (PD-L1) R-PE Conjugate

CD274 (B7-H1, PD-L1, Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells.  It plays an important role in regulation of T cell activation, and is involved in progression of cancer, arthritis and HIV infection (3).  CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation.  Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production.  High levels of CD274 present in Renal cell carcinoma is associated with poor prognosis (1) .  Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival (2).  Gamma Interferon and PHA can up regulate CD274 expression on T cells.

Isotype: Murine IgG1 Kappa

Immunogen: Recombinant human extracellular CD274(B7-H1)

Specificity:  Antibody ANC6H1 binds to recombinant CD274 and native cell surface CD274 expressed on stimulated PBMC.

References:

1)  Cancer Research (April 2006) 66:3381.

2)  J Molecular Medicine (Feb 2004) 81(5):281. 

3)  Int J Hematol (Nov 2003) 78(4):321.

USD $325.00
In cart: 0
= $325.00
Catalog #:
274-050
Form:
R-PE
Size:
120 tests
Alternate Name:
B7-H1, PD-L1, Program Death Ligand
Clone:
ANC6H1
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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