anti-CD269(BCMA) Purified (with Antibiotics)
Isotype: Mouse IgG1k
Immunogen: Recombinant human CD269
INFORMATION : Human CD269 (BCMA, B cell maturation antigen) is predominantly expressed by mature B cells and is a type I TNF superfamily receptor member (TNFRSF17) . It is highly specific for its ligand CD257 (BAFF, Blys).
Antibody ANC3B1 binds to recombinant CD269 (but not CD268) in EIA and native CD269 expressed on cell surface(2). It blocks binding of recombinant soluble CD257(BAFF)trn-muCD8(cat# 525-020) to recombinant CD269(BCMA)-muIg (cat# 519-020) in EIA.
1) Schneider P., J. Tschopp, et al. J. Exp. Med. 1999, 189(11):1747-1756.
2) T Gantke, M Treder, et al. (Sept 2017) Protein Engineering, Design and Selection 30(9): 673-684. PMID 28981915 DOI: 10.1093/protein/gzx043