anti-CD357(GITR)(clone ANC7D6) Biotinylated

Glucocorticoid induced Tumor Necrosis Factor  receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18.  GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break  T cell suppression (2).  GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3).

Clone ANC7D6-1E7 binds to human GITR in EIA and on stimulated cell surface in FACS.  Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

Isotype: Murine IgM kappa

Immunogen: Recombinant human GITR, PHA stimulated human PBL

Specificity: Antibody ANC7D6-1E7 binds to human GITR in EIA and on cell surface in FACS.  Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

References:

1) Gurney AL, et al. (1999) Curr Biol 9(4): 215-218.

2) Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827.

3) Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9.

4) Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10.

5) Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690. .

6) McHugh, R.S. et al. (2002) Immunity 16:311.

7) Shin, H.H. et al. (2002) FEBS Lett. 514:275.

8). Shimizu, J. et al. (2002) Nature Immunol. 3:135.

USD $300.00
In cart: 0
= $300.00
Catalog #:
268-030
Form:
Biotin
Size:
100 µg
Alternate Name:
GITR, AITR, anti-AITR, glucocorticoid induced tumor necrosis, anti-GITR factor, TNFRSF18
Clone:
ANC7D6-1B7
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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