Human Lymphotoxin beta receptor (LTbetaR, TNFRSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary lymphoid organ development(5). Suppression of LTbetaR signaling can alleviate autoimmunity(2) or exasperate mycobacterial infection(6). Its ligands include Ltab 2 and LIGHT. In mice, LTbetaR signaling is important for development and function of HEV(2), Dendritic cells(3), and Mast cells(4).
Isotype: Murine IgG1 kappa
Immunogen: Recombinant Human LT
Specificity: Antibody ANCLTR2 binds to human LTbR present on U-937 cell surface, and to recombinant LTbR-muIg in EIA.
1) T W Mak, M E Saunders eds. The Immune Response 2006 Elsevier Academic Press p 499.
2) J L Browning, R.A. Fava, et al. Immunity (2005) 23(5): 539-50.
3)Y Wang, Y Fu, et al. J Immunol (2005) 175 : 6997-7002.
4) P Stopfer, T Hehlgans, et al. J Immunol (2004) 172: 7459-7465.
5) Gommermann J, JL Browning, et al, Nat Rev Immunol (2003) 3:642-655.
6) Spahn TW, T Kucharzik, et al. Infection and Immunity (2005) 73(11): 7077-7088.