anti-LTβR R-PE Conjugate

Human Lymphotoxin beta receptor (LTbetaR, TNFRSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2).  It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary lymphoid organ development(5). Suppression of LTbetaR signaling can alleviate autoimmunity(2) or exasperate mycobacterial infection(6).  Its  ligands include Ltab 2 and LIGHT.  In mice, LTbetaR signaling is important for development and function of HEV(2), Dendritic cells(3), and Mast cells(4).

Isotype: Murine IgG1 kappa

Immunogen: Recombinant Human LT

Specificity: Antibody ANCLTR2 binds to human LTbR present on U-937 cell surface, and to recombinant LTbR-muIg in EIA.

References:

1) T W Mak, M E Saunders eds. The Immune Response  2006 Elsevier Academic Press p 499. 

2) J L Browning, R.A. Fava, et al. Immunity (2005) 23(5): 539-50. 

3)Y Wang, Y Fu, et al. J Immunol (2005) 175 : 6997-7002.

4) P Stopfer, T Hehlgans, et al. J Immunol (2004) 172: 7459-7465.

5) Gommermann J, JL Browning, et al, Nat Rev Immunol (2003) 3:642-655.

6) Spahn TW, T Kucharzik, et al. Infection and Immunity (2005) 73(11): 7077-7088.

USD $325.00
In cart: 0
= $325.00
Catalog #:
267-050
Form:
R-PE
Size:
120 tests
Alternate Name:
Lymphotoxinβ Receptor, Lymphotoxin beta Receptor, LTbR, TNFSF3, anti-LTbR, LTbR, ANC9E2, ANCLTR2/9E2, LTbetaR
Clone:
ANCLTR2/9E2
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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