The cytokine human interferon-gamma (IFN-gamma) is a glycosylated protein that exists as a homodimer of 34 kd in its biologically active form. IFN-gamma is expressed upon activation by TH1 cells CD8+ cells and NK cells (2). Secreted IFN-gamma is a potent inhibitor of in vitro hematopoiesis and appears to serve as an important regulator of lymphocyte and macrophage function by exerting antiproliferative effects (1). Antibody ANC2E11 binds to recombinant and cellular IFN-gamma in EIA and Flow cytometry.
Isotype: Murine IgG1 kappa
Immunogen: Recombinant human IFN-gamma
1. H.A. Young & K.J. Hardy (1995) J Leuk Biol 58: 373-381.
2. A. Bilkiau (1996) Adv Immunol 62: 61-130.
3. T. Sato, et al (1997) Blood 90: 4749-4758.