Human CD62E (E-selectin) is an adhesion molecule expressed on activated endothelium and facilitates recruitment of leukocytes to sights of acute inflammation and immunological events. CD62E has affinity to Lewisx(1).
Isotype: Murine IgG1
Immunogen: TNF activated HUVEC
Specificity: Antibody HAE-1f recognizes the lectin domain of CD62E (2).
Functional Application: Antibody HAE-1f blocks the function of CD62E. It has been used for FACS analysis of circulating Endothelial Microparticles (4).
1. T.P. Kogan, et al, (1995) J Biol Chem 270: 14047-14055.
2. L. Tu, et al, (1996) J Immunol 157: 3995-4004.
3. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 416-419.