Human CD58 is a cell surface glycoprotein with wide distribution on hemopoetic cells and functions as an adhesion molecule mediating a costimulatory signal through CD2. CD58 is attached to the cell surface by either of two forms – transmembrane or GPI.
Isotype: Murine IgG1
Immunogen: Human cytotoxic T cells
Specificity: Antibody TS2/9 reacts with both transmembrane and GPI anchored CD58.
Functional Application: Antibody TS2/9 will inhibit HLA-DR mediated T cell cytotoxicity (3).
1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 414-415.
2. A.R. Arulanandam, et al, (1994) J Exp Med 180:1861-1871.
3. Vollger LW, Singer KH, et al. (1987) J Immunol 138(2): 358-63.