anti-CD36 FITC Conjugate

Human CD36 is a major platelet glycoprotein also found on monocytes, macrophages and some endothelial cells.  CD36 may play a role in cell adhesion as a receptor for thrombospondin.  CD36 is a receptor for adhesion of malaria infected erythrocytes (2).  CD36 is also proported to have a role in phagocytosis (4).

Isotype: Murine IgM

Immunogen: Human tonsil cells /PBM

Specificity: Antibody SMO recognizes the CD36 molecule of 88 kd (1, 3). Its epitope has been mapped to amino acids 155-183 (5).  Antibody SMO can block phagoctosis of Group A Streptococcus by U-937 cells (6).

References:

1.  N. Hogg, et al, (1984) Immunology  53: 753-767.

2.  P. Oquendo, et al,  (1989) Cell  58: 95-101.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1269-1289.

4.  Y. Ren, et al, (1995) J Exp Med  181: 1857-1862.

5. L. Daviet, J. L. McGregor, et al. (1995) Biochem. J 305: 221-224.

6.  Ling Liu, Runlin Han, et al. (July 2015) Microbiology and Immunology 59(7): 419-425. PMID: 26094502

7. I Soaita, W Yin, D A Rubenstein (Jan 2017) Platelets http://dx.doi.org/10.1080/09537104.2016.1260703