anti-CD27 Purified (Preservative-free)

Human CD27 is a lymphocyte specific member of the tumor necrosis factor (TNF) receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells.  The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily (2, 3).  Antibody M-T271 does not block the interaction between CD27 and CD70.

Isotype: Murine IgG1

Immunogen: T cell line (from patient with CLL)

Specificity:  Antibody M-T271 recognizes the dimeric CD27 molecule of approximately 110 kd (1, 4) but does not block the interaction between CD70 and CD27.  Clone M-T271 has been shown to abrogate IL-4 production(7) or induce apoptosis(6) in  MLR . Clone M-T271 is crossreactive with cynomolgus monkey CD27 (8).

References:

1.  Leukocyte Typing IV  (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 350-352.

2.  K. Agematsu, et al, (1994) J Immunol  153: 1421-1429.

3.  R.Q. Hintzen, et al, (1994) Immunol Today  15: 307-311.

4.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 356-360, 435-437.

5.  K. Agematsu, et al, (1995) J Immunol   154: 3627-3635.

6.  Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7.  Palmer DR, U Krzych. Eur J Immunol 32(3): 652-661.

8. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

USD $175.00
In cart: 0
= $175.00
Catalog #:
176-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
T14
Clone:
M-T271
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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